TRIM59

Entrez Summary: N/A
UniProt Summary: May serve as a multifunctional regulator for innate immune signaling pathways. {ECO:0000250|UniProtKB:Q922Y2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
JQ1 0.01μM R03 exp130	1.8
CCCP 0.1μM R00 exp10	2.29

zf-C3HC4
zf-B box

negative regulation of viral entry into host cell
intraciliary transport particle B
regulation of viral entry into host cell
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral life cycle
negative regulation of viral process
regulation of viral life cycle
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
ubiquitin protein ligase activity
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of intracellular signal transduction
protein ubiquitination
innate immune response
protein modification by small protein conjugation
regulation of multi-organism process
zinc ion binding
endoplasmic reticulum membrane
defense response to other organism
protein modification by small protein conjugation or removal
endoplasmic reticulum
negative regulation of signal transduction
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
regulation of intracellular signal transduction
immune response