TRPM4

Gene Information

Official Symbol: TRPM4
Official Name: transient receptor potential cation channel subfamily M member 4
Aliases and Previous Symbols: N/A
Entrez ID: 54795
UniProt: Q8TD43
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016].
UniProt Summary: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. {ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-2.67
DABN 2μM R00 exp16	-2.36
LLY-283 2.6μM R06 exp290	-2.3
TRAIL 5ng/ml R00 exp35	-2.06
MLN-4924 0.2μM R00 exp21	-1.89
Pimelic-diphenylamide-106 5μM R00 exp28	-1.79
5-Fluorouracil 20μM R00 exp2	-1.73
Torin1 0.08μM R02 exp82	1.71
LJH685 50μM R08 exp433	2.64

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14182
Expression level (log2 read counts): 2.89

Expression Distribution

positive regulation of regulation of vascular smooth muscle cell membrane depolarization
positive regulation of atrial cardiac muscle cell action potential
positive regulation of cardiac conduction
membrane depolarization during bundle of His cell action potential
Purkinje myocyte action potential
membrane depolarization during Purkinje myocyte cell action potential
positive regulation of cardiac muscle cell contraction
positive regulation of actin filament-based movement
Purkinje myocyte to ventricular cardiac muscle cell signaling
membrane depolarization during AV node cell action potential
bundle of His cell action potential
bundle of His cell to Purkinje myocyte signaling
sodium channel complex
positive regulation of adipose tissue development
Purkinje myocyte to ventricular cardiac muscle cell communication
regulation of atrial cardiac muscle cell action potential
spanning component of plasma membrane
spanning component of membrane
AV node cell to bundle of His cell signaling
AV node cell action potential
regulation of adipose tissue development
positive regulation of action potential
AV node cell to bundle of His cell communication
positive regulation of cardiac muscle contraction
positive regulation of membrane depolarization
bundle of His cell to Purkinje myocyte communication
calcium activated cation channel activity
positive regulation of striated muscle contraction
regulation of ventricular cardiac muscle cell action potential
sodium ion import across plasma membrane
membrane depolarization during cardiac muscle cell action potential
dendritic cell chemotaxis
cellular response to ATP
negative regulation of bone mineralization
dendritic cell migration
positive regulation of heart rate
cell-cell signaling involved in cardiac conduction
negative regulation of biomineralization
negative regulation of biomineral tissue development
regulation of cardiac muscle cell action potential