TSNAX

Entrez Summary: N/A
UniProt Summary: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

production of siRNA involved in RNA interference
RNA interference
endoribonuclease activity
dsRNA processing
production of small RNA involved in gene silencing by RNA
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
RNA phosphodiester bond hydrolysis, endonucleolytic
gene silencing by RNA
single-stranded DNA binding
gene silencing
RNA phosphodiester bond hydrolysis
regulation of gene expression, epigenetic
nucleic acid phosphodiester bond hydrolysis
sequence-specific DNA binding
posttranscriptional regulation of gene expression
spermatogenesis
male gamete generation
gamete generation
perinuclear region of cytoplasm
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
RNA processing
Golgi apparatus
multi-organism reproductive process
RNA binding
reproductive process
reproduction
DNA binding
RNA metabolic process
negative regulation of gene expression
gene expression