TSPAN6

Gene Information

Official Symbol: TSPAN6
Official Name: tetraspanin 6
Aliases and Previous Symbols: N/A
Entrez ID: 7105
UniProt: O43657
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14442
Expression level (log2 read counts): 1.22

Expression Distribution

negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of NIK/NF-kappaB signaling
negative regulation of defense response to virus
regulation of defense response to virus
negative regulation of response to biotic stimulus
regulation of NIK/NF-kappaB signaling
negative regulation of immune effector process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of defense response
negative regulation of multi-organism process
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of response to external stimulus
negative regulation of immune system process
regulation of innate immune response
regulation of immune effector process
negative regulation of intracellular signal transduction
regulation of response to biotic stimulus
regulation of cytokine production
regulation of defense response
regulation of multi-organism process
positive regulation of intracellular signal transduction
regulation of response to external stimulus
regulation of immune response
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
integral component of plasma membrane
regulation of response to stress
negative regulation of response to stimulus
regulation of immune system process
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction