TTC30B

Entrez Summary: N/A
UniProt Summary: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Chlorpromazine 10μM R07 exp344	-2.03
Etoposide 0.3μM R05 exp199	1.74

intraciliary transport particle B binding
axonemal microtubule
intraciliary transport particle B
intraciliary transport involved in cilium assembly
ciliary tip
intraciliary transport
microtubule-based protein transport
protein transport along microtubule
ciliary basal body
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
protein-containing complex localization
microtubule-based movement
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule-based process
organelle assembly
intracellular protein transport
plasma membrane bounded cell projection organization
cell projection organization
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport