TWF1
Gene Information
- Official Symbol: TWF1
- Official Name: twinfilin actin binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5756
- UniProt: Q12792
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Cofilin ADF |
GO Terms
| regulation of actin phosphorylation |
| sequestering of actin monomers |
| actin filament depolymerization |
| barbed-end actin filament capping |
| actin monomer binding |
| myofibril |
| positive regulation of cardiac muscle hypertrophy |
| regulation of lamellipodium assembly |
| positive regulation of muscle hypertrophy |
| actin filament capping |
| protein depolymerization |
| negative regulation of actin filament depolymerization |
| regulation of lamellipodium organization |
| actin polymerization or depolymerization |
| regulation of actin filament depolymerization |
| negative regulation of actin filament polymerization |
| regulation of cardiac muscle hypertrophy |
| regulation of muscle hypertrophy |
| negative regulation of protein depolymerization |
| negative regulation of protein polymerization |
| negative regulation of protein complex disassembly |
| filopodium |
| maintenance of protein location in cell |
| phosphatidylinositol-4,5-bisphosphate binding |
| actin filament |
| regulation of protein depolymerization |
| regulation of muscle adaptation |
| protein tyrosine kinase activity |
| ruffle membrane |
| maintenance of location in cell |
| maintenance of protein location |
| regulation of protein complex disassembly |
| negative regulation of protein complex assembly |
| negative regulation of supramolecular fiber organization |
| cellular protein complex disassembly |
| negative regulation of cytoskeleton organization |
| peptidyl-tyrosine phosphorylation |
| peptidyl-tyrosine modification |
| maintenance of location |
| regulation of actin filament polymerization |
| cell-cell junction |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament binding |
| actin cytoskeleton |
| regulation of protein polymerization |
| regulation of muscle system process |
| actin filament organization |
| protein-containing complex disassembly |
| regulation of actin filament organization |
| actin binding |
| positive regulation of neuron projection development |
| cadherin binding |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| positive regulation of neuron differentiation |
| negative regulation of organelle organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| cellular component disassembly |
| focal adhesion |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| actin filament-based process |
| regulation of system process |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| regulation of neurogenesis |
| peptidyl-amino acid modification |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| phosphorylation |
| regulation of organelle organization |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| ATP binding |
| generation of neurons |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| neurogenesis |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UNC2400 2μM R03 exp156 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8953
- Expression level (log2 read counts): 5.43
Expression Distribution
TWF1 Expression in NALM6 Cells: 5.43
