UBE2J2

Gene Information

Official Symbol: UBE2J2
Official Name: ubiquitin conjugating enzyme E2 J2
Aliases and Previous Symbols: N/A
Entrez ID: 118424
UniProt: Q8N2K1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). {ECO:0000255|PROSITE-ProRule:PRU00388}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	-1.91
BI-6727 0.001μM R01 exp42	-1.75
Mitomycin-C 0.06μM R08 exp503	-1.72
Cerivastatin 0.15μM R05 exp226	1.82
Salinomycin 3.5μM R08 exp521	1.96

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5307
Expression level (log2 read counts): 5.42

Expression Distribution

positive regulation of protein targeting to mitochondrion
ubiquitin conjugating enzyme activity
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
ubiquitin-dependent ERAD pathway
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
ERAD pathway
ubiquitin ligase complex
positive regulation of mitochondrion organization
positive regulation of intracellular protein transport
response to unfolded protein
regulation of mitochondrion organization
response to topologically incorrect protein
positive regulation of intracellular transport
regulation of intracellular protein transport
response to endoplasmic reticulum stress
ubiquitin protein ligase binding
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cellular protein localization
proteasomal protein catabolic process
regulation of intracellular transport
positive regulation of protein transport
positive regulation of establishment of protein localization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cellular protein localization
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
positive regulation of organelle organization
protein catabolic process
protein ubiquitination
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
protein modification by small protein conjugation
cellular macromolecule catabolic process
regulation of cellular localization