UBQLN4

Gene Information

Official Symbol: UBQLN4
Official Name: ubiquilin 4
Aliases and Previous Symbols: N/A
Entrez ID: 56893
UniProt: Q9NRR5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9845
Expression level (log2 read counts): 6.54

Expression Distribution

Screen	Score
Cannabidiol 20μM R08 exp466	-2.03
THZ531 0.225μM R08 exp444	-1.92
Oligomycin-A 2μM R00 exp25	-1.85
Rapamycin 2μM R07 exp306	-1.81

ubiquitin
UBA
Rad60-SLD

nuclear proteasome complex
negative regulation of autophagosome maturation
cytosolic proteasome complex
regulation of autophagosome maturation
site of DNA damage
negative regulation of double-strand break repair via homologous recombination
polyubiquitin modification-dependent protein binding
negative regulation of double-strand break repair
negative regulation of macroautophagy
negative regulation of DNA repair
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
autophagosome
negative regulation of protein complex disassembly
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
negative regulation of autophagy
regulation of DNA recombination
regulation of protein complex disassembly
negative regulation of DNA metabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of DNA repair
regulation of ubiquitin-dependent protein catabolic process
regulation of macroautophagy
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of response to DNA damage stimulus
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
cytoplasmic vesicle
autophagy
process utilizing autophagic mechanism
negative regulation of catabolic process
regulation of autophagy
regulation of DNA metabolic process
regulation of protein catabolic process
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process