UGT8

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. {ECO:0000250|UniProtKB:Q09426}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyco tran 28 C
UDPGT

N-acylsphingosine galactosyltransferase activity
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
protein localization to paranode region of axon
galactosylceramide biosynthetic process
galactolipid biosynthetic process
glycosylceramide biosynthetic process
paranodal junction assembly
protein localization to axon
galactosylceramide metabolic process
galactolipid metabolic process
glycosylceramide metabolic process
myelin assembly
UDP-glycosyltransferase activity
glycosphingolipid biosynthetic process
ceramide biosynthetic process
glycosphingolipid metabolic process
glycolipid biosynthetic process
peripheral nervous system development
ceramide metabolic process
sphingolipid biosynthetic process
cellular component assembly involved in morphogenesis
cell-cell junction assembly
myelination
axon ensheathment
ensheathment of neurons
glycolipid metabolic process
liposaccharide metabolic process
membrane lipid biosynthetic process
cell-cell junction organization
sphingolipid metabolic process
cell junction assembly
membrane lipid metabolic process
cell junction organization
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
amide biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process