UNCX

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

common myeloid progenitor cell proliferation
olfactory bulb interneuron differentiation
cartilage condensation
cell aggregation
dorsal spinal cord development
olfactory bulb development
olfactory lobe development
forebrain neuron differentiation
forebrain generation of neurons
spinal cord development
cartilage development
central nervous system neuron differentiation
connective tissue development
skeletal system morphogenesis
telencephalon development
forebrain development
sequence-specific DNA binding
pattern specification process
skeletal system development
cell population proliferation
brain development
head development
animal organ morphogenesis
central nervous system development
neuron differentiation
generation of neurons
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
tissue development
regulation of cell differentiation