UPRT

Entrez Summary: This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.96
AICAR 240μM R03 exp116	-1.76
Deguelin 0.05μM R02 exp69	1.82

pyrimidine ribonucleoside monophosphate biosynthetic process
UMP biosynthetic process
UMP metabolic process
pyrimidine ribonucleoside monophosphate metabolic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine ribonucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
nucleoside monophosphate biosynthetic process
lactation
pyrimidine nucleotide biosynthetic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
body fluid secretion
nucleoside monophosphate metabolic process
kinase activity
pyrimidine-containing compound metabolic process
nucleoside metabolic process
mammary gland development
glycosyl compound metabolic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
female pregnancy
multi-multicellular organism process
response to insulin
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
ribonucleotide metabolic process
ribose phosphate metabolic process
GTP binding
response to peptide hormone
gland development
nucleotide metabolic process
nucleoside phosphate metabolic process
response to peptide
regulation of body fluid levels
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process