UROS

Entrez Summary: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MKC9989 10μM R03 exp133	-2.03
Epigallocatechin gallate 20μM R05 exp230	-1.85
Lead acetate 2000μM R08 exp498 no dilution day6	1.73
35°C R06 exp302	1.75
Cannabidiol 13μM R08 exp465	1.76
GSK-J4 1-1.25μM to day4 R07 exp363	1.76
PF-06409577 20μM R07 exp389	1.8
DABN 2μM R00 exp16	1.9
Fluvastatin 2.2μM R06 exp282	2.15
Rapamycin 1μM R00 exp29	2.32
Artemisinin 50μM R08 exp450	5.21

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

uroporphyrinogen-III synthase activity
response to platinum ion
uroporphyrinogen III metabolic process
cellular response to amine stimulus
uroporphyrinogen III biosynthetic process
protoporphyrinogen IX biosynthetic process
protoporphyrinogen IX metabolic process
cofactor binding
cellular response to arsenic-containing substance
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
response to arsenic-containing substance
porphyrin-containing compound metabolic process
response to amine
pigment biosynthetic process
tetrapyrrole metabolic process
pigment metabolic process
cofactor biosynthetic process
carboxylic acid biosynthetic process
response to antibiotic
organic acid biosynthetic process
response to metal ion
cofactor metabolic process
response to inorganic substance
small molecule biosynthetic process
cellular response to organonitrogen compound
cellular response to nitrogen compound
carboxylic acid metabolic process
response to organonitrogen compound
oxoacid metabolic process
organic acid metabolic process
response to nitrogen compound
heterocycle biosynthetic process
aromatic compound biosynthetic process
cellular response to endogenous stimulus
mitochondrion
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process