USP21

Entrez Summary: N/A
UniProt Summary: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NEDD8-specific protease activity
histone deubiquitination
cysteine-type peptidase activity
thiol-dependent ubiquitinyl hydrolase activity
thiol-dependent ubiquitin-specific protease activity
protein deubiquitination
transcription coactivator activity
protein modification by small protein removal
histone modification
covalent chromatin modification
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
neuron projection development
protein catabolic process
chromatin organization
neuron development
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
neuron differentiation
macromolecule catabolic process
organonitrogen compound catabolic process
chromosome organization
plasma membrane bounded cell projection organization
cell projection organization
proteolysis
generation of neurons
positive regulation of transcription, DNA-templated
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development
positive regulation of RNA metabolic process
organic substance catabolic process
cellular catabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process