USP46

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). {ECO:0000250|UniProtKB:P62069, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:26388029}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docetaxel 0.002μM R01 exp45	1.82
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.91

Gene	Correlation
WDR20	0.524
WDR48	0.464

righting reflex
adult feeding behavior
behavioral response to ethanol
regulation of postsynaptic neurotransmitter receptor internalization
reflex
behavioral fear response
behavioral defense response
regulation of synaptic transmission, GABAergic
fear response
regulation of receptor internalization
thiol-dependent ubiquitinyl hydrolase activity
multicellular organismal response to stress
feeding behavior
cysteine-type endopeptidase activity
regulation of receptor-mediated endocytosis
thiol-dependent ubiquitin-specific protease activity
response to ethanol
adult behavior
regulation of endocytosis
response to alcohol
protein deubiquitination
protein modification by small protein removal
response to antibiotic
glutamatergic synapse
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
response to toxic substance
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cellular protein localization
modification-dependent macromolecule catabolic process
regulation of vesicle-mediated transport
behavior
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
cellular macromolecule catabolic process