USP47
Gene Information
- Official Symbol: USP47
- Official Name: ubiquitin specific peptidase 47
- Aliases and Previous Symbols: N/A
- Entrez ID: 55031
- UniProt: Q96K76
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. {ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:21362556}.
Pfam Domains GO Terms
Pfam Domains
| UCH |
GO Terms
| WD40-repeat domain binding |
| ubiquitinyl hydrolase activity |
| monoubiquitinated protein deubiquitination |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| base-excision repair |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| thiol-dependent ubiquitinyl hydrolase activity |
| SCF ubiquitin ligase complex |
| negative regulation of response to DNA damage stimulus |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to UV |
| negative regulation of G2/M transition of mitotic cell cycle |
| negative regulation of cysteine-type endopeptidase activity |
| cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway |
| negative regulation of cell cycle G2/M phase transition |
| thiol-dependent ubiquitin-specific protease activity |
| cellular response to light stimulus |
| response to UV |
| positive regulation of canonical Wnt signaling pathway |
| regulation of intrinsic apoptotic signaling pathway |
| positive regulation of cell growth |
| cellular response to radiation |
| positive regulation of Wnt signaling pathway |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| negative regulation of cell cycle phase transition |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| positive regulation of growth |
| regulation of canonical Wnt signaling pathway |
| protein deubiquitination |
| regulation of protein stability |
| protein modification by small protein removal |
| negative regulation of mitotic cell cycle |
| response to light stimulus |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| negative regulation of cell cycle process |
| negative regulation of proteolysis |
| regulation of Wnt signaling pathway |
| regulation of apoptotic signaling pathway |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of cell growth |
| response to radiation |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| negative regulation of hydrolase activity |
| negative regulation of intracellular signal transduction |
| DNA repair |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| regulation of growth |
| protein catabolic process |
| regulation of proteolysis |
| regulation of cellular response to stress |
| DNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| negative regulation of catalytic activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| protein modification by small protein conjugation or removal |
| negative regulation of cell death |
| response to drug |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.2μM R00 exp24 | -1.72 |
| Bortezomib 0.005μM R00 exp6 | 1.98 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GOLGA6L1 | 0.433 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8143
- Expression level (log2 read counts): 6.76
Expression Distribution
USP47 Expression in NALM6 Cells: 6.76
