VAMP3
Gene Information
- Official Symbol: VAMP3
- Official Name: vesicle associated membrane protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 9341
- UniProt: Q15836
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.
Pfam Domains GO Terms
Pfam Domains
| Synaptobrevin |
GO Terms
| mucus secretion |
| regulation of histamine secretion by mast cell |
| SNARE complex assembly |
| positive regulation of immunoglobulin secretion |
| positive regulation of receptor recycling |
| regulation of immunoglobulin secretion |
| secretion by tissue |
| regulation of receptor recycling |
| syntaxin-1 binding |
| regulation of mast cell degranulation |
| integral component of synaptic vesicle membrane |
| Golgi to plasma membrane protein transport |
| regulation of mast cell activation involved in immune response |
| vesicle docking involved in exocytosis |
| calcium-ion regulated exocytosis |
| positive regulation of immunoglobulin production |
| regulation of mast cell activation |
| SNARE complex |
| regulation of leukocyte degranulation |
| substrate adhesion-dependent cell spreading |
| establishment of protein localization to plasma membrane |
| clathrin-coated vesicle membrane |
| clathrin-coated vesicle |
| regulation of myeloid leukocyte mediated immunity |
| Golgi to plasma membrane transport |
| vesicle docking |
| regulation of immunoglobulin production |
| exocytic process |
| carbohydrate derivative transport |
| vesicle fusion |
| phagocytic vesicle membrane |
| body fluid secretion |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| organelle membrane fusion |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| recycling endosome membrane |
| secretory granule |
| transport vesicle |
| vesicle-mediated transport to the plasma membrane |
| trans-Golgi network membrane |
| retrograde transport, endosome to Golgi |
| organelle fusion |
| positive regulation of production of molecular mediator of immune response |
| antigen processing and presentation of peptide antigen via MHC class I |
| post-Golgi vesicle-mediated transport |
| recycling endosome |
| membrane fusion |
| regulation of production of molecular mediator of immune response |
| regulation of neurotransmitter transport |
| cytosolic transport |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| organelle localization by membrane tethering |
| antigen processing and presentation of exogenous peptide antigen |
| membrane docking |
| response to interferon-gamma |
| protein localization to plasma membrane |
| antigen processing and presentation of exogenous antigen |
| cell-substrate adhesion |
| antigen processing and presentation of peptide antigen |
| negative regulation of secretion by cell |
| regulation of leukocyte mediated immunity |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of exocytosis |
| endosomal transport |
| protein localization to cell periphery |
| negative regulation of secretion |
| establishment of protein localization to membrane |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| vesicle organization |
| apical plasma membrane |
| neuron projection |
| regulation of inflammatory response |
| regulation of intracellular transport |
| Golgi vesicle transport |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| protein localization to membrane |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of body fluid levels |
| regulation of hormone levels |
| cell junction |
| regulation of vesicle-mediated transport |
| cell morphogenesis involved in differentiation |
| organelle localization |
| regulation of leukocyte activation |
| cell surface |
| regulation of cell activation |
| intracellular membrane-bounded organelle |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| regulation of protein transport |
| cell morphogenesis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| exocytosis |
| regulation of secretion |
| cellular component morphogenesis |
| cellular protein-containing complex assembly |
| membrane organization |
| regulation of cellular localization |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| positive regulation of transport |
| secretion by cell |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| export from cell |
| regulation of response to external stimulus |
| response to cytokine |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cell development |
| regulation of immune system process |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| All-trans-Retinoic-Acid 40μM R07 exp334 | 1.73 |
| Nifurtimox 1μM R03 exp141 | 2 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6367
- Expression level (log2 read counts): 4.62
Expression Distribution
VAMP3 Expression in NALM6 Cells: 4.62
