VIP
Gene Information
- Official Symbol: VIP
- Official Name: vasoactive intestinal peptide
- Aliases and Previous Symbols: N/A
- Entrez ID: 7432
- UniProt: P01282
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. {ECO:0000269|PubMed:15013843}.
Pfam Domains GO Terms
Pfam Domains
| Hormone 2 |
GO Terms
| epinephrine secretion |
| epinephrine transport |
| positive regulation of epinephrine secretion |
| catecholamine secretion |
| prolactin secretion |
| positive regulation of penile erection |
| regulation of penile erection |
| regulation of epinephrine secretion |
| peptide hormone receptor binding |
| positive regulation of catecholamine secretion |
| catecholamine transport |
| monoamine transport |
| neuropeptide hormone activity |
| negative regulation of potassium ion transport |
| positive regulation of amine transport |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| mRNA stabilization |
| negative regulation of smooth muscle cell proliferation |
| RNA stabilization |
| negative regulation of mRNA catabolic process |
| positive regulation of blood vessel diameter |
| peptide hormone secretion |
| negative regulation of RNA catabolic process |
| regulation of catecholamine secretion |
| hormone secretion |
| body fluid secretion |
| positive regulation of reproductive process |
| negative regulation of mRNA metabolic process |
| hormone transport |
| regulation of amine transport |
| positive regulation of endothelial cell proliferation |
| regulation of potassium ion transport |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| hormone activity |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| regulation of endothelial cell proliferation |
| regulation of smooth muscle cell proliferation |
| perikaryon |
| regulation of nervous system process |
| organic hydroxy compound transport |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| cAMP-mediated signaling |
| negative regulation of ion transport |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of reproductive process |
| protein localization to extracellular region |
| signal release |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| peptide secretion |
| regulation of mRNA stability |
| regulation of RNA stability |
| positive regulation of epithelial cell proliferation |
| regulation of mRNA catabolic process |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of protein catabolic process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| negative regulation of cellular catabolic process |
| learning or memory |
| cognition |
| negative regulation of catabolic process |
| neuron projection |
| regulation of mRNA metabolic process |
| regulation of epithelial cell proliferation |
| second-messenger-mediated signaling |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of catabolic process |
| positive regulation of secretion |
| negative regulation of transport |
| regulation of body fluid levels |
| positive regulation of multi-organism process |
| regulation of anatomical structure size |
| posttranscriptional regulation of gene expression |
| regulation of hormone levels |
| behavior |
| regulation of system process |
| negative regulation of cell population proliferation |
| regulation of ion transport |
| regulation of secretion by cell |
| regulation of multi-organism process |
| regulation of secretion |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of catabolic process |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cell-cell signaling |
| secretion |
| G protein-coupled receptor signaling pathway |
| negative regulation of RNA metabolic process |
| nervous system process |
| negative regulation of nucleobase-containing compound metabolic process |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| establishment of protein localization |
| regulation of cell population proliferation |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| nitrogen compound transport |
| regulation of transport |
| extracellular region |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IU1-47 25μM R04 exp182 | 1.71 |
| Dynasore 10μM R04 exp180 | 1.83 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18918
- Expression level (log2 read counts): -7.68
Expression Distribution
VIP Expression in NALM6 Cells: -7.68
