VIPR2

Entrez Summary: N/A
UniProt Summary: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. {ECO:0000269|PubMed:8926282}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Trientine 500μM R08 exp534	-1.87
UNC2400 2μM R03 exp156	1.76

7tm 2
HRM

vasoactive intestinal polypeptide receptor activity
activation of adenylate cyclase activity
peptide hormone binding
G protein-coupled peptide receptor activity
negative regulation of smooth muscle cell proliferation
regulation of smooth muscle cell proliferation
negative regulation of cell population proliferation
G protein-coupled receptor activity
cell-cell signaling
G protein-coupled receptor signaling pathway
integral component of plasma membrane
regulation of cell population proliferation