VTCN1

Gene Information

Official Symbol: VTCN1
Official Name: V-set domain containing T cell activation inhibitor 1
Aliases and Previous Symbols: N/A
Entrez ID: 79679
UniProt: Q7Z7D3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM R07 exp306	-1.71
Staurosporine 0.02μM R08 exp524	-1.7
CVT-10216 0.1μM R06 exp278	1.78
BI-D1870 2μM R04 exp162	1.87
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2
3-Bromopyruvate 7μM R04 exp175	2.09

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13755
Expression level (log2 read counts): -0.8

Expression Distribution

positive regulation of interleukin-2 secretion
interleukin-4 secretion
regulation of interleukin-2 secretion
interleukin-4 production
interferon-gamma secretion
interferon-gamma production
response to protozoan
positive regulation of interleukin-2 production
cytokine secretion
regulation of interleukin-2 production
negative regulation of T cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
negative regulation of leukocyte proliferation
positive regulation of T cell proliferation
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
positive regulation of cytokine secretion
negative regulation of lymphocyte activation
cytokine production
regulation of T cell proliferation
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
T cell receptor signaling pathway
negative regulation of cell activation
positive regulation of T cell activation
regulation of cytokine secretion
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
positive regulation of protein secretion