WHSC1L1

Entrez Summary: This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015].
UniProt Summary: Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PWWP
SET

positive regulation of histone H3-K36 trimethylation
positive regulation of histone H3-K36 methylation
regulation of histone H3-K36 trimethylation
regulation of histone H3-K36 methylation
histone methyltransferase activity (H3-K36 specific)
histone H3-K36 methylation
histone-lysine N-methyltransferase activity
positive regulation of histone methylation
regulation of histone methylation
histone lysine methylation
peptidyl-lysine methylation
positive regulation of histone modification
histone methylation
positive regulation of chromatin organization
chromatin
protein alkylation
protein methylation
regulation of histone modification
positive regulation of chromosome organization
regulation of chromatin organization
macromolecule methylation
transcription coactivator activity
methylation
peptidyl-lysine modification
regulation of chromosome organization
histone modification
covalent chromatin modification
positive regulation of organelle organization
chromatin organization
peptidyl-amino acid modification
chromosome organization
positive regulation of cellular component organization
positive regulation of protein modification process
regulation of organelle organization
positive regulation of transcription, DNA-templated
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of protein metabolic process
positive regulation of RNA metabolic process