WNK3

Gene Information

Official Symbol: WNK3
Official Name: WNK lysine deficient protein kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 65267
UniProt: Q9BYP7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16206
Expression level (log2 read counts): 1.41

Expression Distribution

Screen	Score
All-trans-Retinoic-Acid 40μM R07 exp334	1.82
Dinaciclib 0.007μM R07 exp355	1.94
I-BRD9 4μM R07 exp365	2.43

OSR1 C
Pkinase
Pkinase Tyr

negative regulation of pancreatic juice secretion
regulation of pancreatic juice secretion
positive regulation of potassium ion import across plasma membrane
potassium channel inhibitor activity
regulation of potassium ion import
chloride channel inhibitor activity
positive regulation of sodium ion transmembrane transporter activity
negative regulation of sodium ion transport
negative regulation of digestive system process
positive regulation of sodium ion transmembrane transport
positive regulation of peptidyl-threonine phosphorylation
positive regulation of sodium ion transport
positive regulation of potassium ion transmembrane transport
regulation of calcium ion import
regulation of digestive system process
regulation of peptidyl-threonine phosphorylation
positive regulation of potassium ion transport
regulation of sodium ion transmembrane transporter activity
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to cell periphery
adherens junction
regulation of sodium ion transmembrane transport
regulation of potassium ion transmembrane transport
regulation of sodium ion transport
regulation of protein localization to plasma membrane
regulation of potassium ion transport
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
regulation of protein localization to cell periphery
positive regulation of calcium ion transport
positive regulation of protein localization to membrane
bicellular tight junction
positive regulation of cation transmembrane transport
negative regulation of ion transport
positive regulation of ion transmembrane transport
protein localization to plasma membrane
regulation of protein localization to membrane
protein autophosphorylation
positive regulation of transmembrane transport
protein localization to cell periphery