WNT5A

Gene Information

Official Symbol: WNT5A
Official Name: Wnt family member 5A
Aliases and Previous Symbols: N/A
Entrez ID: 7474
UniProt: P41221
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). {ECO:0000250|UniProtKB:P22725, ECO:0000250|UniProtKB:Q27Q52, ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4579
Expression level (log2 read counts): -1.89

Expression Distribution

chemoattraction of serotonergic neuron axon
receptor tyrosine kinase-like orphan receptor binding
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
planar cell polarity pathway involved in ventricular septum morphogenesis
planar cell polarity pathway involved in outflow tract morphogenesis
negative regulation of cell proliferation in midbrain
planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
planar cell polarity pathway involved in cardiac right atrium morphogenesis
planar cell polarity pathway involved in pericardium morphogenesis
mesodermal to mesenchymal transition involved in gastrulation
planar cell polarity pathway involved in gastrula mediolateral intercalation
cervix development
chemorepulsion of dopaminergic neuron axon
mediolateral intercalation
positive regulation of timing of anagen
chemoattractant activity involved in axon guidance
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
regulation of cell proliferation in midbrain
hypophysis morphogenesis
non-canonical Wnt signaling pathway involved in heart development
lateral sprouting involved in mammary gland duct morphogenesis
planar cell polarity pathway involved in heart morphogenesis
cardiac right atrium morphogenesis
negative regulation of melanin biosynthetic process
diencephalon morphogenesis
optic cup formation involved in camera-type eye development
negative regulation of secondary metabolite biosynthetic process
melanocyte proliferation
planar cell polarity pathway involved in axis elongation
urinary bladder development
chemoattraction of axon
serotonergic neuron axon guidance
epithelial cell proliferation involved in mammary gland duct elongation
negative regulation of prostatic bud formation
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of thymocyte apoptotic process
Wnt signaling pathway involved in heart development
positive regulation of hair follicle maturation
planar cell polarity pathway involved in axon guidance
positive regulation of protein kinase C activity