WNT5B

Entrez Summary: N/A
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
OICR-9429 10μM R03 exp142	-1.74
Palbociclib 1μM R07 exp382	2.24

lens fiber cell development
lens fiber cell differentiation
frizzled binding
positive regulation of fat cell differentiation
endocytic vesicle membrane
cellular response to retinoic acid
lens development in camera-type eye
chondrocyte differentiation
Golgi lumen
fat cell differentiation
response to retinoic acid
regulation of fat cell differentiation
cartilage development
negative regulation of canonical Wnt signaling pathway
epithelial cell development
cellular response to acid chemical
negative regulation of Wnt signaling pathway
connective tissue development
cell fate commitment
regulation of canonical Wnt signaling pathway
endoplasmic reticulum lumen
camera-type eye development
signaling receptor binding
response to acid chemical
cell-cell signaling by wnt
Wnt signaling pathway
eye development
visual system development
regulation of Wnt signaling pathway
collagen-containing extracellular matrix
sensory system development
cell surface receptor signaling pathway involved in cell-cell signaling
wound healing
skeletal system development
positive regulation of cell migration
cellular response to lipid
positive regulation of cell motility
positive regulation of cellular component movement
sensory organ development
positive regulation of locomotion