WNT7B
Gene Information
- Official Symbol: WNT7B
- Official Name: Wnt family member 7B
- Aliases and Previous Symbols: N/A
- Entrez ID: 7477
- UniProt: P56706
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway in vascular smooth muscle cells. Required for normal fusion of the chorion and the allantois during placenta development. {ECO:0000250|UniProtKB:P28047}.
Pfam Domains GO Terms
Pfam Domains
| wnt |
GO Terms
| outer medullary collecting duct development |
| establishment or maintenance of polarity of embryonic epithelium |
| renal inner medulla development |
| fibroblast proliferation |
| renal outer medulla development |
| inner medullary collecting duct development |
| central nervous system vasculogenesis |
| establishment of endothelial blood-brain barrier |
| trachea cartilage morphogenesis |
| metanephric loop of Henle development |
| lobar bronchus development |
| establishment of blood-brain barrier |
| chorio-allantoic fusion |
| oxygen homeostasis |
| trachea cartilage development |
| metanephric collecting duct development |
| bronchus development |
| gas homeostasis |
| loop of Henle development |
| trachea morphogenesis |
| collecting duct development |
| regulation of cell projection size |
| lens fiber cell development |
| metanephric nephron tubule development |
| metanephric nephron epithelium development |
| metanephric tubule development |
| trachea development |
| labyrinthine layer morphogenesis |
| metanephric epithelium development |
| forebrain regionalization |
| embryonic placenta morphogenesis |
| metanephros morphogenesis |
| lens fiber cell differentiation |
| cartilage morphogenesis |
| lung epithelium development |
| establishment of endothelial barrier |
| receptor ligand activity |
| activation of JUN kinase activity |
| frizzled binding |
| lung morphogenesis |
| labyrinthine layer development |
| endothelial cell development |
| stem cell proliferation |
| positive regulation of osteoblast differentiation |
| mammary gland epithelium development |
| endocytic vesicle membrane |
| vasculogenesis |
| cellular response to retinoic acid |
| positive regulation of JUN kinase activity |
| lens development in camera-type eye |
| nephron tubule development |
| renal tubule development |
| JNK cascade |
| endothelial cell differentiation |
| metanephros development |
| kidney morphogenesis |
| positive regulation of ossification |
| regulation of JUN kinase activity |
| embryonic placenta development |
| canonical Wnt signaling pathway |
| endothelium development |
| nephron epithelium development |
| Golgi lumen |
| stress-activated MAPK cascade |
| response to retinoic acid |
| regulation of osteoblast differentiation |
| developmental growth involved in morphogenesis |
| nephron development |
| mammary gland development |
| kidney epithelium development |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| morphogenesis of embryonic epithelium |
| response to glucocorticoid |
| placenta development |
| activation of MAPK activity |
| response to corticosteroid |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| lung development |
| cartilage development |
| respiratory tube development |
| regulation of JNK cascade |
| regulation of ossification |
| epithelial cell development |
| respiratory system development |
| establishment or maintenance of cell polarity |
| cellular response to acid chemical |
| connective tissue development |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| cell fate commitment |
| positive regulation of MAP kinase activity |
| kidney development |
| synapse organization |
| renal system development |
| endoplasmic reticulum lumen |
| camera-type eye development |
| urogenital system development |
| response to steroid hormone |
| activation of protein kinase activity |
| regionalization |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| response to acid chemical |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| eye development |
| visual system development |
| sensory system development |
| MAPK cascade |
| regulation of cellular component size |
| in utero embryonic development |
| forebrain development |
| developmental growth |
| growth |
| signal transduction by protein phosphorylation |
| blood vessel morphogenesis |
| gland development |
| reproductive structure development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| skeletal system development |
| cell-cell adhesion |
| vasculature development |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| cellular response to lipid |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| sensory organ development |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| neuron projection development |
| developmental process involved in reproduction |
| epithelial cell differentiation |
| cell morphogenesis |
| regulation of cellular response to stress |
| brain development |
| regulation of MAPK cascade |
| head development |
| regulation of protein kinase activity |
| neuron development |
| cellular component morphogenesis |
| tube development |
| response to lipid |
| circulatory system development |
| regulation of kinase activity |
| response to hormone |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| chemical homeostasis |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.483 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11105
- Expression level (log2 read counts): 1.4
Expression Distribution
WNT7B Expression in NALM6 Cells: 1.4
