WNT9B

Gene Information

Official Symbol: WNT9B
Official Name: Wnt family member 9B
Aliases and Previous Symbols: N/A
Entrez ID: 7484
UniProt: O14905
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:20093360). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). {ECO:0000250|UniProtKB:O35468, ECO:0000305|PubMed:20093360}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6910
Expression level (log2 read counts): 2.08

Expression Distribution

establishment of planar polarity involved in nephron morphogenesis
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
mesenchymal stem cell maintenance involved in nephron morphogenesis
mesonephric duct formation
kidney rudiment formation
regulation of asymmetric cell division
mesonephric duct morphogenesis
nephric duct formation
uterus morphogenesis
metanephric tubule formation
negative regulation of stem cell population maintenance
mesonephric tubule formation
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
cornea development in camera-type eye
mesonephric duct development
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
metanephric tubule morphogenesis
nephric duct morphogenesis
collecting duct development
midbrain dopaminergic neuron differentiation
co-receptor binding
nephric duct development
nephron tubule formation
metanephric tubule development
regulation of epithelial cell differentiation involved in kidney development
metanephric epithelium development
uterus development
establishment of planar polarity
male genitalia development
regulation of metanephros development
establishment of tissue polarity
regulation of stem cell population maintenance
dopaminergic neuron differentiation
receptor ligand activity
frizzled binding
morphogenesis of a polarized epithelium
branching involved in ureteric bud morphogenesis
embryonic cranial skeleton morphogenesis
genitalia development
ureteric bud morphogenesis