WWC2

Entrez Summary: This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tenofovir 10μM R07 exp405	-2.73
PF-06409577 20μM R07 exp389	-1.92
Diepoxybutane 3μM R07 exp354	-1.9
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.85
2-Methoxyestradiol 0.55μM R07 exp310	-1.8
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.78
Mdivi-1 15μM R05 exp217	-1.71
All-trans-Retinoic-Acid 8μM R07 exp333	-1.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of hippo signaling
regulation of hippo signaling
negative regulation of organ growth
molecular adaptor activity
kinase binding
regulation of organ growth
negative regulation of developmental growth
negative regulation of growth
regulation of developmental growth
negative regulation of intracellular signal transduction
regulation of growth
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of response to stimulus
negative regulation of gene expression
regulation of intracellular signal transduction