WWOX

Entrez Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 1 to 2μM on day4 R04 exp164	-2.28
Tubacin 1.6μM R07 exp416	-2.04
Trimetrexate 0.03μM R08 exp535	-1.97
Q15 2.7μM R02 exp79	-1.8
FTY720 3μM R08 exp483	-1.77
Arsenate 40μM R06 exp264	-1.73
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
coenzyme binding
cofactor binding
regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
microvillus
RNA polymerase II transcription factor complex
extrinsic apoptotic signaling pathway
oxidoreductase activity
signal transduction by p53 class mediator
osteoblast differentiation
intrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
cellular response to transforming growth factor beta stimulus
protein dimerization activity
response to transforming growth factor beta
positive regulation of apoptotic signaling pathway
negative regulation of Wnt signaling pathway
skeletal system morphogenesis
steroid metabolic process
ossification
transcription coactivator activity
apoptotic signaling pathway
enzyme binding
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
regulation of apoptotic signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
skeletal system development
cellular response to growth factor stimulus
response to growth factor
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
negative regulation of transcription by RNA polymerase II
apoptotic process
animal organ morphogenesis
oxidation-reduction process