XRCC1

Gene Information

Official Symbol: XRCC1
Official Name: X-ray repair cross complementing 1
Aliases and Previous Symbols: N/A
Entrez ID: 7515
UniProt: P18887
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. {ECO:0000269|PubMed:28002403}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Talazoparib 0.006μM R06 exp299	-2.64
Rucaparib 6.5μM R08 exp520	-1.94
Temozolomide 200μM R04 exp189	-1.89
Campthothecin 0.001μM R06 exp270	-1.82
Olaparib 4μM R08 exp512	-1.8
Chloramphenicol 2μM R00 exp12	1.71

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	1/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1804
Expression level (log2 read counts): 4.96

Expression Distribution

PTCB-BRCT
BRCT
XRCC1 N

positive regulation of DNA ligase activity
oxidized DNA binding
regulation of DNA ligase activity
positive regulation of single strand break repair
negative regulation of protein ADP-ribosylation
3 overhang single-stranded DNA endodeoxyribonuclease activity
telomeric DNA-containing double minutes formation
negative regulation of protection from non-homologous end joining at telomere
regulation of protection from non-homologous end joining at telomere
base-excision repair, DNA ligation
regulation of single strand break repair
replication-born double-strand break repair via sister chromatid exchange
negative regulation of telomere maintenance in response to DNA damage
regulation of telomere maintenance in response to DNA damage
ERCC4-ERCC1 complex
positive regulation of DNA ligation
regulation of DNA ligation
positive regulation of ligase activity
single strand break repair
voluntary musculoskeletal movement
negative regulation of telomere capping
DNA ligation involved in DNA repair
regulation of ligase activity
regulation of protein ADP-ribosylation
telomere maintenance via recombination
DNA ligation
mitotic recombination
response to hydroperoxide
nucleotide-excision repair, DNA gap filling
regulation of telomere capping
negative regulation of telomere maintenance
cerebellum morphogenesis
base-excision repair
hindbrain morphogenesis
multicellular organismal movement
musculoskeletal movement
double-strand break repair via nonhomologous end joining
non-recombinational repair
positive regulation of DNA repair
transcription-coupled nucleotide-excision repair