YTHDF3

Gene Information

Official Symbol: YTHDF3
Official Name: YTH N6-methyladenosine RNA binding protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 253943
UniProt: Q7Z739
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].
UniProt Summary: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency (PubMed:28106072, PubMed:28106076, PubMed:28281539). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28106076, PubMed:28281539). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (PubMed:28106072, PubMed:28106076). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits (PubMed:28106072, PubMed:28106076). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs) and promotes their translation (PubMed:28281539). circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). {ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 18289
Expression level (log2 read counts): 6.24

Expression Distribution

N6-methyladenosine-containing RNA binding
negative regulation of type I interferon-mediated signaling pathway
positive regulation of translational initiation
mRNA destabilization
RNA destabilization
regulation of type I interferon-mediated signaling pathway
positive regulation of mRNA catabolic process
ribosome binding
negative regulation of innate immune response
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
positive regulation of mRNA metabolic process
regulation of translational initiation
negative regulation of response to biotic stimulus
positive regulation of translation
negative regulation of translation
negative regulation of cellular amide metabolic process
negative regulation of immune response
positive regulation of cellular amide metabolic process
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
negative regulation of defense response
negative regulation of multi-organism process
regulation of mRNA metabolic process
regulation of translation
negative regulation of response to external stimulus
positive regulation of cellular catabolic process
regulation of cellular amide metabolic process
positive regulation of catabolic process
negative regulation of immune system process
regulation of innate immune response
regulation of response to biotic stimulus
posttranscriptional regulation of gene expression
regulation of defense response
regulation of multi-organism process
regulation of cellular catabolic process
regulation of catabolic process