ZDHHC8

Entrez Summary: This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010].
UniProt Summary: Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1. {ECO:0000269|PubMed:19556522}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

high-density lipoprotein particle assembly
palmitoyltransferase activity
plasma lipoprotein particle assembly
protein-cysteine S-palmitoyltransferase activity
protein-lipid complex assembly
protein palmitoylation
plasma lipoprotein particle organization
protein-lipid complex subunit organization
regulation of plasma lipoprotein particle levels
protein lipidation
lipoprotein biosynthetic process
lipoprotein metabolic process
cytoplasmic vesicle membrane
protein acylation
locomotory behavior
extracellular structure organization
behavior
Golgi apparatus
mitochondrion
organonitrogen compound biosynthetic process
protein-containing complex assembly
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization