ZFP91

Gene Information

Official Symbol: ZFP91
Official Name: ZFP91 zinc finger protein
Aliases and Previous Symbols: N/A
Entrez ID: 80829
UniProt: Q96JP5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Deguelin 0.15μM R05 exp209	-2.24
Torin1 0.08μM R02 exp82	-2.07
UM0131023 0.05μM R05 exp248	-1.99
Nifuroxazide 5μM R03 exp102	-1.98
Citral 75μM R06 exp275	-1.91
Cyclosporin-A 0.8μM R07 exp347	-1.9
Senexin-A 25μM R07 exp400	-1.73
GSK-J4 1μM R07 exp362	-1.71
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.79
Olaparib 4μM R08 exp512	1.84
AICAR 240μM R05 exp211	2.19
UM131593 0.2μM R03 exp106	2.43

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3608
Expression level (log2 read counts): 7.18

Expression Distribution

Gene	Correlation
CRLS1	0.441
TRIAP1	0.431
PMM2	0.418
TAZ	0.406

activation of NF-kappaB-inducing kinase activity
protein K63-linked ubiquitination
positive regulation of NIK/NF-kappaB signaling
NIK/NF-kappaB signaling
regulation of NIK/NF-kappaB signaling
nucleic acid binding
ubiquitin-protein transferase activity
protein polyubiquitination
activation of protein kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
protein ubiquitination
protein modification by small protein conjugation
regulation of protein kinase activity
nucleolus
regulation of kinase activity
regulation of transferase activity
protein modification by small protein conjugation or removal
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
positive regulation of catalytic activity
regulation of protein phosphorylation
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
intracellular signal transduction
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process