ZNF606

Gene Information
  • Official Symbol: ZNF606
  • Official Name: zinc finger protein 606
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 80095
  • UniProt: Q8WXB4
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016].
  • UniProt Summary: May act as a transcriptional repressor. {ECO:0000269|PubMed:15964554}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 10656
  • Expression level (log2 read counts): 4.43

Expression Distribution

  • Last modified: 2026/01/07 22:37
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