ZSWIM6

Entrez Summary: The protein encoded by this gene contains a zinc finger SWI2/SNF2 and MuDR (SWIM) domain. Proteins with SWIM domains have been found in a diverse number of species and are predicted to interact with DNA or proteins. Mutations in this gene result in acromelic frontonasal dysostosis. [provided by RefSeq, Apr 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TRAIL 5ng/ml R00 exp35	1.75
NFN1 0.1μM R01 exp49	1.93

striatal medium spiny neuron differentiation
Cul2-RING ubiquitin ligase complex
striatum development
subpallium development
regulation of axon guidance
forebrain neuron differentiation
forebrain generation of neurons
central nervous system neuron differentiation
regulation of axonogenesis
regulation of chemotaxis
telencephalon development
regulation of cell morphogenesis involved in differentiation
forebrain development
regulation of cell morphogenesis
regulation of neuron projection development
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
brain development
head development
regulation of neurogenesis
zinc ion binding
regulation of nervous system development
regulation of cell development
central nervous system development
regulation of locomotion
regulation of cellular component movement
neuron differentiation
regulation of anatomical structure morphogenesis
regulation of response to external stimulus
generation of neurons
neurogenesis
regulation of cell differentiation