UniProt Summary: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}.
Pfam DomainsGO Terms
Pfam Domains
CENP-K
GO Terms
condensed nuclear chromosome inner kinetochore
kinetochore assembly
kinetochore organization
CENP-A containing nucleosome assembly
CENP-A containing chromatin organization
chromatin remodeling at centromere
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
histone exchange
ATP-dependent chromatin remodeling
mitotic sister chromatid segregation
nucleosome assembly
chromatin assembly
sister chromatid segregation
mitotic nuclear division
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
protein-DNA complex assembly
nuclear chromosome segregation
protein-DNA complex subunit organization
chromosome segregation
nuclear division
DNA conformation change
organelle fission
mitotic cell cycle process
mitotic cell cycle
chromatin organization
organelle assembly
cellular protein-containing complex assembly
cell cycle process
chromosome organization
cell cycle
protein-containing complex assembly
protein-containing complex subunit organization
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)