DCUN1D1
Gene Information
- Official Symbol: DCUN1D1
- Official Name: defective in cullin neddylation 1 domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 54165
- UniProt: Q96GG9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250, ECO:0000269|PubMed:25349211}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15862
- Expression level (log2 read counts): 5.49
DCUN1D1 Expression in NALM6 Cells: 5.49
