DIS3L
Gene Information
- Official Symbol: DIS3L
- Official Name: DIS3 like exosome 3'-5' exoribonuclease
- Aliases and Previous Symbols: N/A
- Entrez ID: 115752
- UniProt: Q8TF46
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016].
- UniProt Summary: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'→5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7041
- Expression level (log2 read counts): 6.36
DIS3L Expression in NALM6 Cells: 6.36
