FBXL15
Gene Information
- Official Symbol: FBXL15
- Official Name: F-box and leucine rich repeat protein 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 79176
- UniProt: Q9H469
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| F-box |
GO Terms
| positive regulation of BMP signaling pathway |
| bone mineralization |
| SCF ubiquitin ligase complex |
| dorsal/ventral pattern formation |
| regulation of BMP signaling pathway |
| biomineral tissue development |
| biomineralization |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| ubiquitin-protein transferase activity |
| ossification |
| mitotic cell cycle phase transition |
| regulation of cellular response to growth factor stimulus |
| cell cycle phase transition |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| regionalization |
| proteasomal protein catabolic process |
| post-translational protein modification |
| pattern specification process |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| protein catabolic process |
| mitotic cell cycle |
| protein ubiquitination |
| protein modification by small protein conjugation |
| cellular macromolecule catabolic process |
| protein modification by small protein conjugation or removal |
| cell cycle process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| proteolysis |
| cell cycle |
| positive regulation of signal transduction |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| B02 10μM R08 exp453 | -1.83 |
| Latrunculin-B 10μM R07 exp374 | -1.75 |
| SGC0649 7μM R03 exp150 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17127
- Expression level (log2 read counts): 3.2
Expression Distribution
FBXL15 Expression in NALM6 Cells: 3.2
