GOSR1
Gene Information
- Official Symbol: GOSR1
- Official Name: golgi SNAP receptor complex member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9527
- UniProt: O95249
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10375
- Expression level (log2 read counts): 6.23
GOSR1 Expression in NALM6 Cells: 6.23
