HIST1H1B
Gene Information
- Official Symbol: H1-5
- Official Name: H1.5 linker histone, cluster member
- Aliases and Previous Symbols: N/A
- Entrez ID: 3009
- UniProt: P16401
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Linker histone |
GO Terms
| establishment of protein localization to chromatin |
| positive regulation of histone H3-K9 methylation |
| establishment of protein localization to chromosome |
| nucleosome positioning |
| negative regulation of chromatin silencing |
| nuclear heterochromatin |
| regulation of histone H3-K9 methylation |
| protein localization to chromatin |
| nuclear euchromatin |
| negative regulation of gene silencing |
| regulation of chromatin silencing |
| positive regulation of histone methylation |
| chromosome condensation |
| nucleosomal DNA binding |
| negative regulation of DNA recombination |
| negative regulation of chromatin organization |
| protein localization to chromosome |
| positive regulation of gene expression, epigenetic |
| regulation of histone methylation |
| nucleosome |
| chromatin DNA binding |
| positive regulation of histone modification |
| double-stranded DNA binding |
| regulation of DNA recombination |
| positive regulation of chromatin organization |
| histone deacetylase binding |
| nucleosome assembly |
| negative regulation of DNA metabolic process |
| regulation of gene silencing |
| negative regulation of chromosome organization |
| chromatin assembly |
| regulation of histone modification |
| chromatin assembly or disassembly |
| nucleosome organization |
| positive regulation of cell growth |
| positive regulation of chromosome organization |
| protein stabilization |
| DNA packaging |
| regulation of chromatin organization |
| protein-DNA complex assembly |
| regulation of gene expression, epigenetic |
| nuclear chromatin |
| protein-DNA complex subunit organization |
| positive regulation of growth |
| regulation of protein stability |
| muscle organ development |
| DNA conformation change |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| negative regulation of organelle organization |
| regulation of cell growth |
| establishment of protein localization to organelle |
| muscle structure development |
| positive regulation of organelle organization |
| regulation of growth |
| chromatin organization |
| negative regulation of cellular component organization |
| protein localization to organelle |
| cellular protein-containing complex assembly |
| negative regulation of transcription by RNA polymerase II |
| chromosome organization |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5097
- Expression level (log2 read counts): 0.13
Expression Distribution
HIST1H1B Expression in NALM6 Cells: 0.13
