HMMR
Gene Information
- Official Symbol: HMMR
- Official Name: hyaluronan mediated motility receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 3161
- UniProt: O75330
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008].
- UniProt Summary: Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q00547}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17797
- Expression level (log2 read counts): 6.45
HMMR Expression in NALM6 Cells: 6.45
