HNF1B
Gene Information
- Official Symbol: HNF1B
- Official Name: HNF1 homeobox B
- Aliases and Previous Symbols: N/A
- Entrez ID: 6928
- UniProt: P35680
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
- UniProt Summary: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Pfam Domains GO Terms
Pfam Domains
| HNF-1B C |
| Homeobox |
| HNF-1 N |
GO Terms
| regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis |
| hepatoblast differentiation |
| negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis |
| mesonephric duct formation |
| pronephric nephron tubule development |
| regulation of pronephros size |
| negative regulation of mesenchymal cell apoptotic process involved in metanephros development |
| pronephric nephron development |
| pronephros morphogenesis |
| regulation of mesenchymal cell apoptotic process involved in metanephros development |
| mesonephric duct morphogenesis |
| regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| negative regulation of somatic stem cell population maintenance |
| negative regulation of mesonephros development |
| regulation of branch elongation involved in ureteric bud branching |
| regulation of kidney size |
| nephric duct formation |
| endodermal cell fate specification |
| ureteric bud elongation |
| regulation of somatic stem cell population maintenance |
| negative regulation of apoptotic process involved in morphogenesis |
| negative regulation of apoptotic process involved in development |
| mesonephric tubule formation |
| inner cell mass cell differentiation |
| negative regulation of stem cell population maintenance |
| mesonephric duct development |
| pronephros development |
| negative regulation of metanephros development |
| negative regulation of mesenchymal cell apoptotic process |
| regulation of mesenchymal cell apoptotic process |
| regulation of apoptotic process involved in morphogenesis |
| regulation of apoptotic process involved in development |
| nephric duct morphogenesis |
| hepatocyte differentiation |
| endodermal cell fate commitment |
| negative regulation of kidney development |
| nephric duct development |
| nephron tubule formation |
| embryonic digestive tract morphogenesis |
| positive regulation of transcription initiation from RNA polymerase II promoter |
| regulation of branching involved in ureteric bud morphogenesis |
| regulation of metanephros development |
| regulation of mesonephros development |
| positive regulation of DNA-templated transcription, initiation |
| regulation of transcription initiation from RNA polymerase II promoter |
| cell fate commitment involved in formation of primary germ layer |
| regulation of stem cell population maintenance |
| proximal promoter sequence-specific DNA binding |
| embryonic digestive tract development |
| negative regulation of animal organ morphogenesis |
| regulation of DNA-templated transcription, initiation |
| blastocyst formation |
| insulin secretion |
| endodermal cell differentiation |
| endoderm formation |
| digestive tract morphogenesis |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| regulation of morphogenesis of a branching structure |
| peptide hormone secretion |
| circadian regulation of gene expression |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| hormone secretion |
| pancreas development |
| endoderm development |
| nephron tubule development |
| renal tubule development |
| hormone transport |
| kidney morphogenesis |
| ureteric bud development |
| epithelial cell proliferation |
| mesonephric epithelium development |
| mesonephric tubule development |
| cell fate specification |
| mesonephros development |
| nephron epithelium development |
| blastocyst development |
| formation of primary germ layer |
| developmental growth involved in morphogenesis |
| embryonic epithelial tube formation |
| nephron development |
| Notch signaling pathway |
| liver development |
| hepaticobiliary system development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| digestive tract development |
| epithelial tube formation |
| response to glucose |
| circadian rhythm |
| response to hexose |
| digestive system development |
| morphogenesis of embryonic epithelium |
| tube formation |
| response to monosaccharide |
| hindbrain development |
| protein secretion |
| stem cell differentiation |
| morphogenesis of a branching epithelium |
| establishment of protein localization to extracellular region |
| gastrulation |
| protein localization to extracellular region |
| morphogenesis of a branching structure |
| signal release |
| response to carbohydrate |
| peptide secretion |
| regulation of morphogenesis of an epithelium |
| protein-DNA complex assembly |
| transcription factor complex |
| anterior/posterior pattern specification |
| protein-DNA complex subunit organization |
| cell fate commitment |
| regulation of animal organ morphogenesis |
| protein-containing complex binding |
| kidney development |
| rhythmic process |
| renal system development |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| urogenital system development |
| regulation of developmental growth |
| regionalization |
| regulation of Wnt signaling pathway |
| in utero embryonic development |
| developmental growth |
| growth |
| gland development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| protein heterodimerization activity |
| regulation of anatomical structure size |
| regulation of hormone levels |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of growth |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| brain development |
| head development |
| cellular protein-containing complex assembly |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to organic cyclic compound |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| secretion by cell |
| response to drug |
| export from cell |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| cell-cell signaling |
| secretion |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| protein transport |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| amide transport |
| establishment of protein localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinamide 1000μM R03 exp101 | 1.76 |
| HMS-I1 1μM R01 exp46 | 1.81 |
| RO-3306 3 to 4μM on day4 R04 exp165 | 1.83 |
| Mdivi-1 15μM R05 exp217 | 2.19 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 52/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 4/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 4/16 |
| kidney | 12/21 |
| liver | 4/20 |
| lung | 6/75 |
| lymphocyte | 0/16 |
| ovary | 3/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 1/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 7956
- Expression level (log2 read counts): -0.25
Expression Distribution
HNF1B Expression in NALM6 Cells: -0.25
