IQGAP1
Gene Information
- Official Symbol: IQGAP1
- Official Name: IQ motif containing GTPase activating protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8826
- UniProt: P46940
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.
Pfam Domains GO Terms
Pfam Domains
| RasGAP |
| RasGAP C |
| CH |
GO Terms
| positive regulation of peptidyl-tyrosine autophosphorylation |
| regulation of peptidyl-tyrosine autophosphorylation |
| glomerular visceral epithelial cell development |
| slit diaphragm |
| glomerular epithelial cell development |
| GTPase inhibitor activity |
| S100 protein binding |
| positive regulation of vascular associated smooth muscle cell migration |
| glomerular visceral epithelial cell differentiation |
| renal filtration cell differentiation |
| glomerular epithelial cell differentiation |
| cellular response to platelet-derived growth factor stimulus |
| glomerular epithelium development |
| response to platelet-derived growth factor |
| regulation of vascular associated smooth muscle cell migration |
| mitogen-activated protein kinase binding |
| small GTPase binding |
| positive regulation of focal adhesion assembly |
| response to angiotensin |
| positive regulation of protein autophosphorylation |
| protein serine/threonine kinase activator activity |
| epithelial cell differentiation involved in kidney development |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| platelet-derived growth factor receptor signaling pathway |
| positive regulation of smooth muscle cell migration |
| phosphatidylinositol-3,4,5-trisphosphate binding |
| cell differentiation involved in kidney development |
| cellular response to epidermal growth factor stimulus |
| negative regulation of GTPase activity |
| response to epidermal growth factor |
| regulation of protein autophosphorylation |
| molecular adaptor activity |
| epidermal growth factor receptor signaling pathway |
| positive regulation of cell-matrix adhesion |
| glomerulus development |
| Rac GTPase binding |
| lateral plasma membrane |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| regulation of smooth muscle cell migration |
| neuron projection extension |
| extrinsic component of cytoplasmic side of plasma membrane |
| regulation of adherens junction organization |
| cytoplasmic ribonucleoprotein granule |
| ERBB signaling pathway |
| positive regulation of dendrite development |
| fibroblast growth factor receptor signaling pathway |
| actin filament |
| cellular response to calcium ion |
| protein phosphatase binding |
| developmental cell growth |
| regulation of cell junction assembly |
| cell growth |
| ruffle |
| nephron epithelium development |
| secretory granule membrane |
| cellular response to fibroblast growth factor stimulus |
| negative regulation of dephosphorylation |
| developmental growth involved in morphogenesis |
| regulation of cell-matrix adhesion |
| response to fibroblast growth factor |
| positive regulation of cell-substrate adhesion |
| nephron development |
| kidney epithelium development |
| growth cone |
| regulation of dendrite development |
| response to calcium ion |
| microtubule cytoskeleton |
| midbody |
| positive regulation of peptidyl-tyrosine phosphorylation |
| epithelial cell development |
| cellular response to metal ion |
| calmodulin binding |
| regulation of cell-substrate adhesion |
| regulation of dephosphorylation |
| actin cytoskeleton |
| cellular response to inorganic substance |
| membrane raft |
| protein domain specific binding |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of MAP kinase activity |
| protein-containing complex binding |
| kidney development |
| positive regulation of neuron projection development |
| GTPase activator activity |
| renal system development |
| axon |
| cadherin binding |
| microtubule |
| urogenital system development |
| neuron projection |
| positive regulation of cellular protein localization |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| positive regulation of neuron differentiation |
| response to metal ion |
| positive regulation of cell projection organization |
| developmental growth |
| response to peptide hormone |
| growth |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| focal adhesion |
| negative regulation of hydrolase activity |
| protein kinase binding |
| positive regulation of neurogenesis |
| response to peptide |
| neuron projection morphogenesis |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| neutrophil degranulation |
| cell projection morphogenesis |
| neutrophil activation involved in immune response |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| neutrophil activation |
| granulocyte activation |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| leukocyte degranulation |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| response to growth factor |
| positive regulation of protein kinase activity |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of cell adhesion |
| epithelial cell differentiation |
| regulation of cytokine production |
| regulation of plasma membrane bounded cell projection organization |
| viral process |
| regulated exocytosis |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| calcium ion binding |
| cell morphogenesis |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| symbiotic process |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of kinase activity |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| immune effector process |
| epithelium development |
| secretion |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| cell projection organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| locomotion |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ethanol 0.003 R08 exp437 | -1.99 |
| BI-2536 0.02μM R03 exp96 | -1.95 |
| Fluvastatin 2.2μM R06 exp282 | -1.93 |
| UM0011500 5μM R05 exp245 | -1.75 |
| Vitamin-D3 40μM R08 exp536 | 1.72 |
| MK-1775 0.32μM R02 exp75 | 1.83 |
| Vemurafenib 6.6μM R02 exp89 | 1.99 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.476 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4189
- Expression level (log2 read counts): 9.41
Expression Distribution
IQGAP1 Expression in NALM6 Cells: 9.41
