L3MBTL3
Gene Information
- Official Symbol: L3MBTL3
- Official Name: L3MBTL histone methyl-lysine binding protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 84456
- UniProt: Q96JM7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016].
- UniProt Summary: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11637
- Expression level (log2 read counts): 3.73
L3MBTL3 Expression in NALM6 Cells: 3.73
