LGALS9
Gene Information
- Official Symbol: LGALS9
- Official Name: galectin 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 3965
- UniProt: O00182
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Gal-bind lectin |
GO Terms
| disaccharide binding |
| regulation of activated T cell autonomous cell death |
| positive regulation of activated T cell autonomous cell death |
| positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response |
| regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response |
| positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
| regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
| natural killer cell tolerance induction |
| positive regulation of dendritic cell apoptotic process |
| positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| positive regulation of interleukin-12 secretion |
| galactose binding |
| mature conventional dendritic cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell proliferation |
| positive regulation of interleukin-13 secretion |
| toll-like receptor 2 signaling pathway |
| positive regulation of dendritic cell differentiation |
| regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| galactoside binding |
| p38MAPK cascade |
| negative regulation of mast cell degranulation |
| positive regulation of interleukin-10 secretion |
| positive regulation of interferon-gamma secretion |
| regulation of interleukin-12 secretion |
| positive regulation of dendritic cell chemotaxis |
| negative regulation of CD4-positive, alpha-beta T cell proliferation |
| negative regulation of mast cell activation involved in immune response |
| positive regulation of viral entry into host cell |
| regulation of dendritic cell chemotaxis |
| regulation of interleukin-10 secretion |
| regulation of dendritic cell apoptotic process |
| regulation of interleukin-13 secretion |
| negative regulation of alpha-beta T cell proliferation |
| positive regulation of monocyte chemotactic protein-1 production |
| regulation of CD4-positive, alpha-beta T cell proliferation |
| negative regulation of myeloid leukocyte mediated immunity |
| regulation of interferon-gamma secretion |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| negative regulation of activated T cell proliferation |
| negative regulation of mast cell activation |
| regulation of dendritic cell differentiation |
| negative regulation of leukocyte degranulation |
| tolerance induction |
| positive regulation of T cell apoptotic process |
| negative regulation of natural killer cell mediated cytotoxicity |
| positive regulation of regulatory T cell differentiation |
| negative regulation of natural killer cell mediated immunity |
| positive regulation of interleukin-8 secretion |
| positive regulation of interleukin-13 production |
| regulation of monocyte chemotactic protein-1 production |
| regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| negative regulation of leukocyte mediated cytotoxicity |
| positive regulation of lymphocyte apoptotic process |
| positive regulation of alpha-beta T cell proliferation |
| negative regulation of chemokine production |
| positive regulation of transforming growth factor beta production |
| toll-like receptor 4 signaling pathway |
| positive regulation of tumor necrosis factor secretion |
| negative regulation of cell killing |
| regulation of interleukin-5 production |
| regulation of interleukin-13 production |
| positive regulation of interleukin-4 production |
| regulation of interleukin-8 secretion |
| negative regulation of regulated secretory pathway |
| regulation of interleukin-4 production |
| positive regulation of leukocyte apoptotic process |
| ERK1 and ERK2 cascade |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| regulation of tumor necrosis factor secretion |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of regulatory T cell differentiation |
| regulation of viral entry into host cell |
| regulation of alpha-beta T cell proliferation |
| positive regulation of interleukin-6 secretion |
| cellular response to virus |
| dendritic cell differentiation |
| negative regulation of interferon-gamma production |
| positive regulation of interleukin-1 beta secretion |
| regulation of T cell apoptotic process |
| negative regulation of exocytosis |
| regulation of mast cell degranulation |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of interleukin-12 production |
| regulation of transforming growth factor beta production |
| regulation of mast cell activation involved in immune response |
| regulation of activated T cell proliferation |
| positive regulation of interleukin-10 production |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of alpha-beta T cell activation |
| positive regulation of interleukin-1 secretion |
| regulation of p38MAPK cascade |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of mast cell activation |
| regulation of natural killer cell mediated immunity |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-8 production |
| negative regulation of leukocyte mediated immunity |
| regulation of leukocyte degranulation |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-10 production |
| regulation of lymphocyte apoptotic process |
| regulation of interleukin-12 production |
| regulation of interleukin-1 secretion |
| positive regulation of chemokine production |
| negative regulation of innate immune response |
| positive regulation of interleukin-1 production |
| regulation of myeloid leukocyte mediated immunity |
| negative regulation of tumor necrosis factor production |
| regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of T cell proliferation |
| positive regulation of alpha-beta T cell activation |
| negative regulation of intracellular transport |
| positive regulation of viral life cycle |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of alpha-beta T cell differentiation |
| positive regulation of interferon-gamma production |
| maternal process involved in female pregnancy |
| regulation of interleukin-8 production |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of leukocyte mediated cytotoxicity |
| regulation of chemokine production |
| negative regulation of leukocyte proliferation |
| regulation of interleukin-1 beta production |
| positive regulation of T cell differentiation |
| regulation of leukocyte apoptotic process |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of leukocyte chemotaxis |
| regulation of alpha-beta T cell activation |
| negative regulation of response to biotic stimulus |
| positive regulation of lymphocyte differentiation |
| positive regulation of interleukin-6 production |
| regulation of interleukin-1 production |
| positive regulation of T cell proliferation |
| regulation of interferon-gamma production |
| toll-like receptor signaling pathway |
| regulation of cell killing |
| stress-activated MAPK cascade |
| positive regulation of viral process |
| regulation of NIK/NF-kappaB signaling |
| negative regulation of T cell activation |
| myeloid leukocyte differentiation |
| regulation of leukocyte chemotaxis |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| pattern recognition receptor signaling pathway |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of chemotaxis |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| stress-activated protein kinase signaling cascade |
| negative regulation of lymphocyte activation |
| regulation of viral life cycle |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of T cell proliferation |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| regulation of lymphocyte differentiation |
| positive regulation of endopeptidase activity |
| carbohydrate binding |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| positive regulation of apoptotic signaling pathway |
| female pregnancy |
| response to interferon-gamma |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of hemopoiesis |
| positive regulation of peptidase activity |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| response to interleukin-1 |
| positive regulation of T cell activation |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of viral process |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| multi-multicellular organism process |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| negative regulation of multi-organism process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| myeloid cell differentiation |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of leukocyte proliferation |
| regulation of exocytosis |
| negative regulation of secretion |
| innate immune response-activating signal transduction |
| regulation of stress-activated MAPK cascade |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| response to virus |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| leukocyte differentiation |
| positive regulation of innate immune response |
| enzyme binding |
| regulation of intracellular transport |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| collagen-containing extracellular matrix |
| negative regulation of response to external stimulus |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| regulation of apoptotic signaling pathway |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| regulation of endopeptidase activity |
| positive regulation of cell activation |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| negative regulation of immune system process |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| negative regulation of transport |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| hemopoiesis |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| regulation of secretion |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| defense response to other organism |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| multi-organism reproductive process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IU1-47 25μM R04 exp182 | 1.77 |
| UM0011500 5μM R05 exp245 | 1.78 |
| Monensin 0.3μM R08 exp507 | 1.83 |
| GSK591 2.6μM R03 exp128 | 1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8380
- Expression level (log2 read counts): -0.02
Expression Distribution
LGALS9 Expression in NALM6 Cells: -0.02
