LMX1B
Gene Information
- Official Symbol: LMX1B
- Official Name: LIM homeobox transcription factor 1 beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 4010
- UniProt: O60663
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
- UniProt Summary: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2253
- Expression level (log2 read counts): 2.02
LMX1B Expression in NALM6 Cells: 2.02
