MRGBP
Gene Information
- Official Symbol: MRGBP
- Official Name: MRG domain binding protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 55257
- UniProt: Q9NV56
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 586
- Expression level (log2 read counts): 5.09
MRGBP Expression in NALM6 Cells: 5.09
