PAICS
Gene Information
- Official Symbol: PAICS
- Official Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Aliases and Previous Symbols: N/A
- Entrez ID: 10606
- UniProt: P22234
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SAICAR synt |
| AIRC |
GO Terms
| phosphoribosylaminoimidazole carboxylase activity |
| 5-amino-4-imidazole carboxylate lyase activity |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| de novo IMP biosynthetic process |
| IMP biosynthetic process |
| purine nucleobase biosynthetic process |
| IMP metabolic process |
| purine nucleoside monophosphate biosynthetic process |
| purine ribonucleoside monophosphate biosynthetic process |
| nucleobase biosynthetic process |
| purine nucleobase metabolic process |
| ribonucleoside monophosphate biosynthetic process |
| purine ribonucleoside monophosphate metabolic process |
| purine nucleoside monophosphate metabolic process |
| nucleobase metabolic process |
| nucleoside monophosphate biosynthetic process |
| pigment biosynthetic process |
| ribonucleoside monophosphate metabolic process |
| pigment metabolic process |
| nucleoside monophosphate metabolic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| cadherin binding |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| carbohydrate derivative biosynthetic process |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| identical protein binding |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 73/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 5/28 |
| blood | 6/28 |
| bone | 1/26 |
| breast | 6/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 4/21 |
| liver | 0/20 |
| lung | 13/75 |
| lymphocyte | 4/16 |
| ovary | 1/26 |
| pancreas | 3/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 4/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 259
- Expression level (log2 read counts): 8.64
Expression Distribution
PAICS Expression in NALM6 Cells: 8.64
