PDXK
Gene Information
- Official Symbol: PDXK
- Official Name: pyridoxal kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 8566
- UniProt: O00764
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Pfam Domains GO Terms
Pfam Domains
| PfkB |
| Phos pyr kin |
GO Terms
| pyridoxal 5-phosphate salvage |
| pyridoxal kinase activity |
| lithium ion binding |
| pyridoxal phosphate biosynthetic process |
| vitamin B6 biosynthetic process |
| pyridoxal phosphate metabolic process |
| vitamin B6 metabolic process |
| aldehyde biosynthetic process |
| sodium ion binding |
| water-soluble vitamin biosynthetic process |
| potassium ion binding |
| vitamin biosynthetic process |
| cellular metabolic compound salvage |
| pyridine-containing compound biosynthetic process |
| pyridine-containing compound metabolic process |
| pyridoxal phosphate binding |
| cellular aldehyde metabolic process |
| specific granule lumen |
| water-soluble vitamin metabolic process |
| secretory granule lumen |
| vitamin metabolic process |
| coenzyme biosynthetic process |
| organic hydroxy compound biosynthetic process |
| cofactor biosynthetic process |
| magnesium ion binding |
| coenzyme metabolic process |
| cofactor metabolic process |
| organic hydroxy compound metabolic process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| drug metabolic process |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| organophosphate biosynthetic process |
| cell population proliferation |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| zinc ion binding |
| protein homodimerization activity |
| organophosphate metabolic process |
| leukocyte activation |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6056
- Expression level (log2 read counts): 5.93
Expression Distribution
PDXK Expression in NALM6 Cells: 5.93
