RAD17
Gene Information
- Official Symbol: RAD17
- Official Name: RAD17 checkpoint clamp loader component
- Aliases and Previous Symbols: N/A
- Entrez ID: 5884
- UniProt: O75943
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Rad17 |
GO Terms
| Rad17 RFC-like complex |
| DNA clamp loader activity |
| mitotic DNA replication checkpoint |
| DNA replication checkpoint |
| mitotic G2/M transition checkpoint |
| negative regulation of DNA replication |
| chromosome, telomeric region |
| negative regulation of G2/M transition of mitotic cell cycle |
| negative regulation of cell cycle G2/M phase transition |
| mitotic DNA integrity checkpoint |
| regulation of DNA replication |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| mitotic cell cycle checkpoint |
| regulation of signal transduction by p53 class mediator |
| cell cycle checkpoint |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| DNA replication |
| negative regulation of cell cycle phase transition |
| nuclear chromatin |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| chromatin binding |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| DNA repair |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| DNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| nucleolus |
| cell cycle process |
| regulation of cell cycle |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hydroxyurea 100μM R07 exp329 | -1.91 |
| Pterostilbene 16μM R02 exp78 | -1.9 |
| MK-1775 0.32μM R02 exp75 | -1.8 |
| Resveratrol 16μM R03 exp147 | -1.75 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| KPNA4 | 0.431 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 243/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 10/28 |
| blood | 7/28 |
| bone | 8/26 |
| breast | 17/33 |
| central nervous system | 11/56 |
| cervix | 1/4 |
| colorectal | 3/17 |
| esophagus | 6/13 |
| fibroblast | 0/1 |
| gastric | 7/16 |
| kidney | 13/21 |
| liver | 7/20 |
| lung | 27/75 |
| lymphocyte | 3/16 |
| ovary | 13/26 |
| pancreas | 3/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 3/15 |
| prostate | 0/1 |
| skin | 9/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 13/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1343
- Expression level (log2 read counts): 5.87
Expression Distribution
RAD17 Expression in NALM6 Cells: 5.87
