RNGTT
Gene Information
- Official Symbol: RNGTT
- Official Name: RNA guanylyltransferase and 5'-phosphatase
- Aliases and Previous Symbols: N/A
- Entrez ID: 8732
- UniProt: O60942
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. {ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9473487, ECO:0000269|PubMed:9512541}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 203
- Expression level (log2 read counts): 5.83
RNGTT Expression in NALM6 Cells: 5.83
